Dopamine signalling and GPR6
We study dopamine signalling and the role of the G protein-coupled receptor 6 (GPR6) in striatal function and behaviour — and develop tools that lay the groundwork for imaging GPR6 in the living brain.
Project page →Translational Molecular Neuroimaging · Aarhus University
Landau Lab.
We investigate how brain disorders and treatments affect molecular signalling and brain function, with a particular focus on Parkinson's disease and depression.
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01 Research
Focus areas
Four research themes, connected by a shared platform of imaging methods and biological validation.
Synaptic imaging
We use imaging of the synaptic vesicle protein SV2A, including PET with [¹¹C]UCB-J, to investigate changes associated with disease and treatment — and how they relate to synaptic density.
What can SV2A PET tell us? →Brain stimulation and neuromodulation
We use PET to investigate how interventions such as deep brain stimulation and vagus nerve stimulation affect brain function and molecular processes, connecting animal models with clinical research.
Publications →Neuroinflammation and glial responses
We develop and apply imaging approaches to study neuroinflammation and glial responses in models of neurological and psychiatric disease, including the molecular targets TSPO and CSF1R.
Publications →02 Approach
From signal to evidence
Careful measurement first; interpretation that stays close to the data.
Using positron emission tomography (PET) and quantitative autoradiography in rodents and minipigs, we study molecular targets in the living brain and in brain tissue. We combine imaging with behavioural testing and neurochemical, molecular and histological analyses to understand what imaging signals represent biologically and how they change with disease and treatment.
Collaborations in radiochemistry, MRI, molecular biology, histology and neurosurgery support tracer development and validation, experimental interventions and interpretation of imaging findings.
- MethodsPET · quantitative autoradiography · behavioural testing · tissue analyses
- ModelsRodents and Göttingen minipigs
- SupportLundbeck Foundation Ascending Investigator Grant (2024) · AUFF Nova (2025)
- UnitTranslational Neuropsychiatry Unit · Dept. of Clinical Medicine, Aarhus University
03 People
The lab
Led by the principal investigator, with a team of researchers, students, and clinicians.
Anne M. Landau
Associate Professor & Principal Investigator
Translational Neuropsychiatry Unit · Aarhus University, Denmark
Anne leads the lab's work in translational molecular neuroimaging: how brain disorders and treatments affect molecular signalling and brain function, with a particular focus on Parkinson's disease and depression.
Team profiles — each with a portrait and a sentence in their own words — are in preparation. See the people page →
Join the lab. We welcome enquiries from prospective PhD students, postdocs, and project students with an interest in molecular imaging, neuroscience, and translational research.
Get in touch04 Publications
Selected work
A selection across our research themes. The full, searchable list includes 80 peer-reviewed articles and reviews.
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2023
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2020
Browse all publications → · Institutional record: Aarhus University research portal ↗
05 Contact
Get in touch
For collaboration, prospective positions, or general enquiries about our imaging work, we would be glad to hear from you.
[email protected]Address
Landau Lab · Translational Neuropsychiatry Unit
Department of Clinical Medicine
Aarhus University, Aarhus, Denmark
Department of Clinical Medicine
Aarhus University, Aarhus, Denmark
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